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In moderate-to-severe HS, apremilast has shown promising activity in several case reports, a small randomized trial and an open-label phase 2 study, with clinically relevant reductions in inflammatory lesions and DLQI, supporting its consideration as an oral option when standard systemic therapies are inadequate or not tolerated [88,89,90,91]

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World Scientific Publishing Company, Singapore, pp 211244, 328pp von Lampe K (2012) The changing role of China in the global illegal cigarette trade

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