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inhibition of PRMT5 or METTL3 disrupts this process, enhancing cisplatin toxicity [120]

Both types of regulation involve the transcriptional factor Yap1p ( Bioinformatic analysis of transcription factor binding sites (TFBS) localised in the promoter region of GSH1 of S.bacillaris revealed two proteins that can potentially be involved in its transcriptional regulation (Azf1p and Tec1p), while five other proteins (Aft2p, Aft1p, Gis1p, Pho4p and Rlm1p) are putatively involved in the regulation of GSH2

Preclinical studies have demonstrated that melatonin effectively mitigates lipid peroxidation, improves mitochondrial dysfunction, suppresses neuroinflammation, and reduces the loss of nigrostriatal dopaminergic neurons

Non-degradable polymers or cross-linked hydrogels can extend ion release longevity for biomedical and environmental applications (Woniak-Budych et al., 2024)