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Of the enlarging number of programmed cell death pathways 9 , parthanatos is uniquely characterized by its dependence on PARP-1 overactivation mediated AIF translocation to the nucleus 21

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78 NNK is known to be a potent lung carcinogen, but also shows tumor induction activity in the nasal cavity, the pancreas, and the liver, whereas NNN has been shown to induce tumors along the respiratory tract and esophagus in various animal models