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or (2) be used with tobacco products or for human consumption." The important premise is that "they change or affect the performance of tobacco products and are used with tobacco products." Closed e-cigarettes, such as closed cartridges or disposable e-cigarettes, obviously cannot change "performance, ingredients, components, or properties" by adding e-liquid, nor can they be "used with tobacco products or for human consumption." This is why Reno dared to claim in the interview: These devices are completely independent and incompatible with any tobacco products, so there is no need to seek FDA approval

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But, this is when the toughest withdrawal symptoms show up