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As a stimulant substance, nicotine causes changes in the sympathetic nervous system, triggering an increase in adrenaline and noradrenaline

Expression of epithelial cell markers in differentiated PBEC from COPD patients and non-COPD patients Validation and characterization of the differentiation of PBEC was conducted by TEER (as an indication of the integrity of the formation of the epithelial barrier during differentiation) and by gene expression analysis of cell type-specific markers of basal and luminal epithelial cells on day 0 (undifferentiated) versus day 28 (fully differentiated)

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