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10.1016/j.bbcan.2020.188437 107 JoostenS

The only clinical trial in which NA was used to treat a renal disease showed that NA treatment in CKD patients produced a reduction in phosphorous levels and an increase in the eGFR, accompanied by beneficial cardiovascular outcomes such as increased HDL and decreased triglyceride levels (Table 2) [182]

doi: 10.7554/eLife.80721 84 SunXGaoYLiZHeJWuY

In contrast, Gram-positive bacteria activate macrophages through cell wall components such as peptidoglycan and teichoic acid, which bind to TLR2, resulting in a comparatively weaker immune response (Elson et al, 2007