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Post-mortem brain tissues of BD patients also revealed higher levels of HNE-4 compared to nonpsychiatric, non-neurologic controls [154]

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The following additional adverse reactions were reported by greater than 1% but not more than 5% of the Depakote ER-treated patients in controlled clinical trials: Body as a Whole: Back Pain, Flu Syndrome, Infection, Infection Fungal Cardiovascular System: Hypertension Digestive System: Constipation, Dry Mouth, Flatulence Hemic and Lymphatic System: Ecchymosis Metabolic and Nutritional Disorders Peripheral Edema Musculoskeletal System: Myalgia Nervous System: Abnormal Gait, Hypertonia, Tremor Respiratory System: Rhinitis Skin and Appendages: Pruritus, Rash Special Senses: Conjunctivitis Urogenital System: Urinary Tract Infection, Vaginitis Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity