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Chronic HG has been linked to advanced glycation end products AGEs formation, which in turn activates intracellular signaling and promotes the expression of pro-inflammatory transcription factors and the release of various inflammatory cytokines (93)

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Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis

Oral supplements work for many people, and injections are another reliable option, especially for those who are already symptomatic and confirmed low