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Labeling was strongest in symbiosomes with mature bacteroids from cells in the nitrogen fixation zone (Figures 1JL, 5B) and weakest in senescent bacteroids (Figure 4C and Table 2)

Given that NRF2 regulates the expression of numerous genes associated with oxidative stress and inflammation, the application of omics methodologies, which allow for the simultaneous measurement of hundreds to thousands of molecular targets, may help to fully delineate how NRF2 activity influences the complex interplay between redox homeostasis and sleep regulation

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