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Although some transcriptomic rewiring might be caused by general stress signalling associated with tumour growth, 120 exposure to various microenvironmental factors, such as signalling molecules, stromal cells, metabolites or hypoxia couldin a premetastatic but already advanced cancer cellinduce stable transcriptional responses that eventually increase metastatic fitness

These requests help prioritize upcoming protocol coverage, especially for compounds that are moving from forum chatter into active research demand

Despite thiopurines being used in the management IBD for over 60 years, many clinicians are still hesitant to use them due to perceptions around limited efficacy and poor tolerance

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