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SST-INs sustain synaptic plasticity-dependent pyramidal cell activation, with SST loss correlated to pyramidal destabilisation and reduced motor learning in mice 69

Volkow, N.D., Frieden, T.R., Hyde, P.S., & Cha, S.S

Traditional nootropic supplements and smart drugs act broadly across brain chemistry, while these peptides switch on narrow, defined pathways such as BDNF or GABA-A

These designs can reveal whether a ligand expresses different apparent potency or efficacy profiles across receptor states, and whether the kinetic signature changes with receptor subtype