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Dopaminergic neurons, which are highly dependent on mitochondrial oxidative phosphorylation for energy, are particularly susceptible to -syn-mediated mitochondrial damage

Yu F, Zeng H, Lei M, Xiao DM, Li W, Yuan H, et al

Immune cells and their products can have both pro-tumor and anti-tumor effects, and modulating the immune response is an important strategy in cancer therapy ( In cervical cancer models, dual PA-coupled toll-like receptor agonists have demonstrated the ability to stimulate M2 macrophage depletion and induce anti-tumor immune responses ( 5.4 Autophagy Autophagy, a process of cellular self-degradation and recycling, plays a significant role in various pathological processes, including malignant transformation, tumor progression, and immune responses in cancer treatment

Investigative efforts so far concerning enterotypes, such as alpha diversity, the Firmicutes-to-Bacteroidetes ratio, aim at the identification of an MDD-specific fecal signature (Valles-Colomer et al., 2019)