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For example, FOXO transcription factors, which activate ATGs such as BECN1, ULK1 , and ATG12 , are precisely regulated through posttranslational modifications

The transcriptional regulation of DNL is mainly orchestrated by two key transcription factors: sterol regulatory element-binding protein 1c (SREBP1c), which is activated by insulin and liver X receptor , and carbohydrate regulatory element-binding protein (ChREBP), which is activated by carbohydrates [41,42,43] (Fig