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In cirrhotic patients peripheral blood mononuclear cells and gastric cancer cell lines, palmitoylcarnitine (C16:0) has been shown to directly integrate into the mitochondrial membrane, inducing membrane potential collapse, ROS production, and cytochrome c release, ultimately activating caspase-mediated apoptosis [124, 125]

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Acetyl-L-carnitine in neuropathic pain: experimental data

In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012