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Emerging evidence suggests that TAM predominantly exhibits the immunosuppressive M2-like phenotype and has increased lipid accumulation in TME by upregulating CD36 (67, 68)

Research has shown that various oligosaccharides can counteract imbalances in the microbiota by encouraging the growth of Lactobacilli , reducing Proteobacteria populations, and lowering the Firmicutes / Bacteroidetes ratio in diet-induced obese rodents [93,94,95]