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Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)

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This action may contribute to improved metabolic health and other associated benefits

The body uses B12 slowly over time, with excess amounts stored for future use, allowing the vitamin to remain in the body for weeks or even months