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However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

REFERENCES Ozone Therapy: What It Is, Uses and Side Effects: Ozonation of Whole Blood Results in an Increased Release of Microparticles from Blood Cells: A Novel Molecular Approach for Enhancing the Safety of Ozone in Autohemotherapy and Insights into Heme Pocket Autoxidation of Hemoglobin: Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment: Hypoxia: Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease: What do we really know about antioxidants?: Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities: Oxidative stress: an evolving definition: The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics: Ozone therapy for skin diseases: Cellular and molecular mechanisms: Classification of White Blood Cells: A Comprehensive Study Using Transfer Learning Based on Convolutional Neural Networks: Silent Ischemia and Ischemic Heart Disease: A systematic review of ozone therapy for treating chronically refractory wounds and ulcers: Disorders of the Immune System: Fibromyalgia: Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy: Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis: Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review: Potential Role of OxygenOzone Therapy in Treatment of COVID-19 Pneumonia: What Is Anemia?: Glucose-6-phosphate dehydrogenase deficiency: The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy:

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