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2, alters fundamental properties including effective particle size, surface charge, chemical composition, and dissolution kinetics, which in turn dictate the materials transport, bioavailability, and hazard potential.6971 Critical transformations include aggregation and agglomeration with natural colloids (heteroaggregation), dissolution and reprecipitation, surface oxidation or reduction, and the formation of an adsorbed layer of natural organic matter, termed the eco-corona

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Acrylamide, a popular cysteine-targeting warhead widely used in approved covalent drugs due to its superior selectivity and exellent pharmacokinetic properties 54 , was incorporated as well