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Immunometabolism in the pathogenesis of vitiligo is one of the most attractive research areas, which raised by the melanocytes from vitiligo patients are more susceptible to oxidative stress and finally lead to activation of the innate immune response and subsequently to adaptive immune response through activation of autoreactive cytotoxic CD8 + T cells

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Carson, University of Tennessee Health Science Center (UTHSC), United States Reviewed by Tsutomu Matsubara, Osaka City University, Japan Jordi Muntan, Institute of Biomedicine of Seville (CSIC), Spain Updates Copyright 2022 Zhou, Zheng and Chen

These findings highlight the critical balance of GSH synthesis and cysteine redox state in regulating oxidative stress, fibroblast behavior, and fibrotic progression