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J Biol Chem 286(24):2166721677

Furthermore, FN can be covalently conjugated to scaffolds or hydrogels due to disulfide bonds present in the FN I and FN II domains, while the FN III domain lacks such bonds

Patients need to understand what the research suggests, what remains uncertain, and why symptoms such as chronic diarrhea, abdominal pain, blood in the stool, unexplained fatigue, rashes, food reactions, or suspected inflammatory bowel disease deserve proper evaluation