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Activated Chk1/2 then phosphorylate and inhibit the phosphatase CDC25

Enhancing the redox activity of lysosomal iron through genetic interventions to eradicate cancer cells is challenging

As a novel iron chelating agent and oxidative phosphorylation inhibitor, VLX600 can induce non-caspase-dependent cell death in glioblastoma (GBM) cells (Reisbeck et al., 2023)