glutathione peroxidase chemical structure The family: Discoveries and mechanism Ebselen

The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

The latter is a lipophilic radical scavenger that acts as an inhibitor of ferroptosis [82]

10.1074/jbc.M512655200 79 YangC.GuoX.DongF.MengF.WangL.WangP.et al (2022)

Two reduced glutathione molecules are formed from every glutathione disulfide and NADPH