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ARA-290 received FDA Orphan Drug Designation for this indication TRPV1-mediated pain models ARA-290 demonstrated specific inhibition of TRPV1 channel activity, relieving capsaicin-induced mechanical hypersensitivity in pre-clinical nociceptor models Complex Regional Pain Syndrome (CRPS) investigational studies have examined ARA-290 in CRPS models due to its dual anti-inflammatory and nociceptor-targeting mechanism Chronic neuropathic pain multiple studies confirm ARA-290 reduces neuroinflammation in the spinal cord by suppressing TNF-, IL-1, and other pro-inflammatory cytokines that maintain chronic pain states Neuroprotection and CNS Research: Cerebral ischaemia/stroke models Wang et al

The nuclear-encoded mitochondrial enzyme MUT uses B 12 as a cofactor for the catabolism of branched-chain amino acids via isomerization of methylmalonyl-CoA to succinyl-CoA, for use in the tricarboxylic acid cycle (Extended Data Fig

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Key activity nodes and flow relationships were extracted