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doi: 10.2174/1872214809666150806105737 224 SamsamikorMDaryaniNEAslPRHekmatdoostA

This modulation of inflammatory signaling occurs through activation of the PI3K/AKT pathway, which possesses intrinsic anti-inflammatory properties including inhibition of pro-inflammatory cytokine release and enhancement of cellular stress resistance

However, its explicit role in the Y-H transition is yet to be explored [121]

In a 1995 review of 295 cases of liver transplant for acute liver failure, APAP toxicity was the leading cause for liver transplantation, representing 20% of that cohort