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(I know, I know this is the hardest part!) If youre as impatient as I am, you can slice into it after about 2 hours

In the absence of serine hydroxymethyl transferase 2 (SHMT2), which catalyzes the first step of mitochondrial one-carbon metabolism, T cell abundance is diminished after antigen-specific activation, due to decreased nucleotide and glutathione synthesis (51, 67)

In conclusion, we show that APAP toxicity in HepG2 cells is largely independent of oxidative stress, and is linked instead to a decoupling of glycolysis from the TCA cycle, lactic acidosis, reduced NADPH production, and subsequent suppression of the anabolic pathways required for rapid growth

& Perfetto, M