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Commonly used target detection methods such as immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are subject to inter-laboratory variability, ambiguous cutoff definitions, and limited quantitative precision [304, 305]

5B, C) but not pHBV1.3-HBs

To address these challenges, emerging strategies such as nanoencapsulation and advanced delivery systems have been developed to enhance bioavailability and improve targeting mechanisms [28, 94, 216]

Furthermore, it is evident that EVs can induce oxidative stress by delivering reactive oxygen species or by modulating the antioxidant defenses of recipient cells