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After treatment, 100 L of CCK-8 working solution was added to each well of the 96-well plate, followed by incubation at 37 C and 5% CO 2 in the dark for 1 h

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Morita W, Snelling SJB, Wheway K, Watkins B, Appleton L, Murphy RJ, Carr AJ, Dakin SG

Acute Phase Reaction In patients given Reclast at randomization and placebo at Month 12, Reclast was associated with signs and symptoms of an acute phase reaction: myalgia (20.4%), fever (19.3%), chills (18.2%), pain (13.8%), headache (13.3%), fatigue (8.3%), arthralgia (6.1%), pain in extremity (3.9%), influenza-like illness (3.3%), and back pain (1.7%), which occurred within the first 3 days following the dose of Reclast