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Consequently, therapeutic strategies aimed at restoring proteostasis have emerged as central disease-modifying approaches

Furthermore, GLO1 can undergo modifications such as phosphorylation at Thr107 and nitrosylation at Cys139 [17]

Also, substituents on the C-5 position in the quinoline ring play a crucial role, not only in the phototoxicity but also the photostability of the fluoroquinolones [179] suggesting that some fluoroquinolones are more resistant than others to photodegradation and hence would have a longer residence time in skin cells (Fig

[PubMed] [Google Scholar] 3.Ungaro R., Mehandru S., Allen P.B., Peyrin-Biroulet L., Colombel J.F