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Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions

ROS are reactive forms of oxygen which include superoxide anion radical, hydrogen peroxide, singlet oxygen and hydroxyl radical, they are usually produced during normal metabolism of oxygen inside the mitochondria [116]

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Patients were randomized to receive one of the following: Treatment continued in both arms until disease progression or unacceptable toxicity