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The reports mentioned above are qualitative in nature, and the loss of quantitative definition directly limits insights into what features are reproducible across studies

Collins BC, Laakkonen EK, Lowe DA (2019) Aging of the musculoskeletal system: how the loss of estrogen impacts muscle strength

Poly ADP-ribosylation, also known as PARylation, is a type of PTM in which polymers of ADP-ribose are covalently attached to target proteins by PAR polymerase (PARP) enzymes, resulting in a dramatic electrostatic change of the acceptor protein surface 128

By contrast lets revisit the elephants butt and insert the lollipop in the muscle