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doi: 10.1111/resp.12109 67 RyuYJKimEJKohWJKimHKwonOJChangJH

Upon conjugation with glutathione, the selectivity index of epothilone towards the tumor cell lines was increased by about 5.7 folds, ensuring their higher solubility, facilitating the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6, 41, 53, 78]

This wide variation is thought to be due to differences in the xenobiotic, the plant species or tissue studied and the time of harvest

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