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The ELF GSH levels that occur with the initial adaptive response are roughly 500-600 M (Figure 1A and 4A) while the GSH levels for the maintained adaptive response over repeated CS exposures are only about 250-300 M (Figure 1A)

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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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