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86 DRAM1 participates in the regulation of autophagy and apoptosis in intestinal epithelial cells by positively regulating JNK, and knockdown of DRAM1 can lead to a decrease in the phosphorylation levels of c-Jun and JNK, inhibit the formation of autophagosomes, and alleviate the symptoms of UC

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According to the included studies, lycopene may show high promise in the management of digestive precancerous lesions, such as relieving mouth opening and burning sensation of oral submucous fibrosis (OSF), presenting potentially equivalent efficacy on managing oral lichen planus (OLP) as steroids and alleviating gastrointestinal precancers symptoms, meanwhile lowering colon cancer risk