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Nuclear recruitment of neuronal nitric-oxide synthase by alpha-syntrophin is crucial for the induction of mitochondrial biogenesis

Necroptosis has been shown to be strongly associated with vitiligo, as melanocytes from perilesional skin affected by vitiligo were significant for necroptosis markers, such as phosphorylated RIP3 and a phosphorylated mixed-lineage kinase-like domain

In terms of receptor activation, chlordane+PCB126 activated hepatic xenobiotic receptors, namely CAR ( Cyp1b10 ) and AHR ( Cyp1a2 ) but PXR ( Cyp3a11 ) was activated only in males, implicating how sex+HFD interactions impact these receptors as potential drivers of toxicant-induced hepatic metabolic disruption and possibly injury

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