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Clinical Benefits & Side Effects Observations from Phase 2 human clinical trials

10.3390/pathogens10010015 37 GrgovS.TasiT.Radovanovi-DiniB.Benedeto-StojanovD

We further discuss how TAM-derived cytokines, lipid mediators, and iron-handling proteins orchestrate a microenvironment that either promotes or restrains ferroptotic cell death

Expression of the T cell co-stimulatory molecule CD80 was only slightly increased on CD11b + /CD45 low microglia during de-and remyelination whereas CD40 and CD86 were not detected or only marginally expressed, suggesting that the co-stimulatory capacity of microglia in the cuprizone model was not sufficient to activate T cells