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Molecules 26(21):6640 Liu L, Chen Y, Zeng R-F, Liu Y, Xie S-S, Lan J-S et al (2021) Design and synthesis of novel 3, 4-dihydrocoumarins as potent and selective monoamine oxidase-B inhibitors with the neuroprotection against Parkinsons disease

BRCA1/2 plays a role in the homologous recombination repair of double-stranded DNA, and tumor cells containing mutations in the BRCA1/2 gene have defective DNA repair due to a deficiency in homologous recombination repair [28, 29] PARP is a key enzyme for repairing DNA single-strand damage, and based on BRCA functional defects, PARP inhibitors are used to suppress its activity and block DNA damage repair, leading to excessive accumulation of DNA damage and ultimately to tumor cell death

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Acute kidney injury (AKI) : A subset of AKD characterized by kidney damage or dysfunction that occurs for seven days or less