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Twenty-four hours after meldonium treatment, the TMAO levels in urine were 3.6 times lower [69]

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( Response: We acknowledge the complexity of the HEBA and refer readers to the discussion in the proposed rule (89 FR 61888) detailing how the HEBA is calculated and applied as well as to the Shared Savings Program's Program Guidance & Specifications web page, [573] where we anticipate publishing details on the HEBA calculation in a future version of the Shared Savings and Losses, Assignment and Quality Performance Standard Methodology Specifications