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moreover, the GNCsiRNA complexes do not require additional chemical modifications to facilitate entry into cells

In addition, we show that knockout of P-gp from drug resistant CHO R C5 (e.g., CHO R C5 PgpA1 , and CHO R C5 PgpA3 ) cells completely reverses the collateral sensitivity of CHO R C5 cells to tamoxifen to the same level as AuxB1 or AuxB1 Pgp cells