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doi: 10.3390/polym14153004 36 XuLLWangMWangYKChenYJZhangYXZhangYQet al

The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

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The Cleveland Clinic notes that bariatric surgery patients are at increased risk for vitamin deficiencies and often require ongoing supplementation: Individuals Using GLP-1 Medications GLP-1 receptor agonists (such as semaglutide and tirzepatide) are commonly used for metabolic health and weight management