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By blocking the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, curcumin prevents the generation of highly inflammatory lipid mediators like leukotrienes (LTC4) and prostaglandins (PGD2)

Furthermore, a randomized clinical trial demonstrated that combining daptomycin with fosfomycin for MRSA bacteremia resulted in a 12% higher success rate compared to daptomycin alone, and led to a 17.8% reduction in mortality in vancomycin-resistant Enterococcus bloodstream infections (Pujol et al., 2021)

[PubMed] [Google Scholar] 77.Whitehead RE, Ferrer JV, Javitch JA, Justice JB

The study reported no significant toxicity, apart from gastrointestinal symptoms (diarrhea, nausea, and flatulence) which were managed symptomatically with minimal impact on quality of life 97