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Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

Glutathione is an example of dipeptide c

Low oral bioavailability, limited intestinal permeability, and extensive presystemic processing may substantially limit systemic exposure and complicate doseresponse interpretation across studies (Liu et al., 2005