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For the purposes of the present document, gene therapy involves the transfer of nucleic acid encoding a modified FX polypeptide provided herein

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Intranasal administration of a hematopoietic growth factor, which has limited capacity to cross the bloodbrain barrier, is 812 times more effective than subcutaneous application in brain and CSF delivery [83]

Importantly, recent reports showed that about 211% of patients with COVID-19 had underlying chronic liver disease (Jothimani et al., 2020) and that abnormal liver function is rather common in the course of the malady