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Liang TT, Zhang Q, Sun WX, Xin Y, Zhang ZG, Tan Y, et al

Downstream to chemical damage, unrepaired biological structures can trigger cascading cellular events which may ultimately determine cell malfunctioning and death or unrestricted replication leading to cancer [15]

This was done by replacing the 3,4,5-trimethoxyphenyl moiety at R 1 with several heteroarylmethylamino and hydroxylamine groups, as it was proven in the same study that the 3,4,5-trimethoxyphenyl at R 1 is not crucial for PDE5 inhibitory activity