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(2019) 29:627637.e5

The idea that the insula wrongly assigns salience to painful stimuli, contributing to heightened pain perception through increased insula activity in Crohns disease, is further supported by the fact that increased functional connectivity (FC) between the SN and the ECN has also been observed in IBD patients ( These findings suggest that the elevated levels of Glx and Gln observed in our study could reflect increased insula activity in Crohns disease patients

This approach is affordable and easy to implement, but its specificity is low as ferritin and related markers are affected by inflammation and liver disease (94)

however, either (a) DNA analysis of the parents showed one of them to be an asymptomatic mutation carrier