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Inflammation induced by disturbances in one-carbon metabolism can set in motion a series of events that contribute to the pathogenesis of Alzheimers and Parkinsons diseases, including altered gene expression, chronic inflammation, and oxidative stress, ultimately influencing the onset and progression of these neurodegenerative disorders

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This work enhances the interpretability of vMRI measures, advances understanding of HD progression, and supports the use of vMRI as an imaging biomarker for drug development Other authorsSee publication Safety and Efficacy of Flexible-dose Deutetrabenazine in Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial (ARTISTS 1) JAMA Open Network In this randomized, double-blind, placebo-controlled study of deutetrabenazine in children and adolescents with Tourette syndrome, the primary efficacy end point was not met

2023 Oct 17 [cited