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Inflammatory cytokines IL-1 and IL-18 present in the ovarian tissue and FF in PCOS patients alter the follicular microenvironment by binding to receptors like IL-1R and TLR4 on the GCs, activating NF-B, which subsequently translocates into the nucleus (50)

However, it is important that the activation of Nrf2 caused by spices is usually transient and reversible, depending on the metabolism of those active ingredients, which is completely different from the continuous and dysregulated activation in cancer (135, 136)

For example, in the strategy of targeting immune organ rejuvenation, a phase II clinical trial demonstrated the potential of miR-205 mimics to restore thymopoiesis in settings of diminished or impaired T cell output

Moreover, while the upstream regulatory molecules of the ferroptotic process have been the focus of considerable attention, our knowledge of the downstream molecular players remains alarmingly scarce