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Monitoring of amitriptyline levels should be considered for patients taking valproate concomitantly with amitriptyline

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Liu J., Xu Y., Hu Y., Wang G

Ammonium accumulation weakens the acidic environment of the lysosome, preventing effective perforin maturation or causing its degradation, thus diminishing its cytotoxic activity

264,265 Interestingly, in Rnf43/Znrf3 mutants, hepatocytes remain in a proliferative state after regeneration is initiated, failing to properly halt the process