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doi: 10.1007/s10989-020-10110-x 91 De BeerA.VivierM

The intricate labyrinthine architecture of the cecal mucosa exponentially amplifies the colonization landscape for microbial inhabitants, while the delicately thin cecal epithelium facilitates the expeditious translocation of fermentation-derived SCFAs into systemic circulation

Once inside, NF-B binds to specific DNA sequences, thereby regulating the transcription of target genes and promoting the production and release of inflammatory cytokines such as TNF-, interleukin (IL)-2, IL-6, and interferon-gamma (INF-)