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Reported results have shown that the addition of pharmacological ascorbate to platinum-based chemotherapy significantly improves tumor deterioration in the advanced stage of NSCLC, by meeting its primary endpoint with an objective response rate of 34.2% and reaching a disease-control rate of 84.2%

Glossary ROS reactive oxygen species Fe 2+ ferrous iron PUFAs polyunsaturated fatty acids GPX4 glutathione peroxidase 4 ACSL4 acyl-CoA synthetase long-chain family member 4 PTGS2 prostaglandin-endoperoxide synthase 2 GSH glutathione SLC7A11 solute carrier family 7 member 11 RSL3 (1S,3R)-RSL3 PRDX3 peroxiredoxin 3 SARS-CoV severe acute respiratory syndrome coronavirus HBV hepatitis B virus EBV Epstein-Barr virus RV rotavirus H1N1 pandemic influenza A virus subtype H1N1 JEV Japanese encephalitis virus P

5 By the 18th century, it had gained wider recognition concerning spontaneous tumor regression in the context of severe bacterial infections

The mass error for precursor ions was set to 20 ppm for the first search and 5 ppm for the main search, and the mass error for fragment ions was set as 0.02 Da