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By incorporating patient-specific data, such as genetic markers and tumor microenvironment characteristics, MSN-based treatments could be customized for maximum efficacy

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Emerging modalities such as electro-fields therapy 4 and focused ultrasound therapy 5 have also shown promising advancements in solid tumor therapy in clinic or pre-clinical settings

Ethics declarations Ethical approval and consent to participate Animals were treated according to the EU council directive 2010/63/EU and the German Law on Animal Protection with approvals for breeding and the procedures by the respective government agency (Lower Saxony State Office for Consumer Protection and Food Safety)